Elf5 - breast cancer's little helper
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چکیده
منابع مشابه
The Guardian's Little Helper: MicroRNAs in the p53 Tumor
Several microRNAs (miRNAs) have been implicated in tumor development based on both changes in their expression patterns and gene structural alterations in human tumors. However, we are only now beginning to see how miRNAs interact with classic oncogene and tumor suppressor mechanisms. Several recent studies have implicated the miR-34 family of miRNAs in the p53 tumor suppressor network. The exp...
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BACKGROUND Elf5, an epithelial specific Ets transcription factor, plays a crucial role in the pregnancy-associated development of the mouse mammary gland. Elf5(-/-) embryos do not survive, however the Elf5(+/-) mammary gland displays a severe pregnancy-associated developmental defect. While it is known that Elf5 is crucial for correct mammary development and lactation, the molecular mechanisms ...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2013
ISSN: 1465-542X
DOI: 10.1186/bcr3397